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Effective Methods for Cleaning Up After Mice and Rodents

Effective Methods for Cleaning Up After Mice and Rodents

Discovering unwelcome rodents in your home can be more than a nuisance; it can pose serious health risks and create a need for a thorough and careful cleanup. This guide explores the most effective methods for cleaning up after mice and rodents. The sooner you detect a rodent infestation, the better. Mice and rats can be shy and are often detected by signs rather than sightings. Look for:

  • Droppings: Small, brown feces are a clear sign of rodent activity. Fresh droppings are usually soft, while older ones become hard and brittle.
  • Nests: Rodents love to create cozy spaces out of soft materials like insulation, paper, and fabric.
  • Gnawing Marks: They might chew on furniture, wires, and even walls.
  • Noises: Scratching or scampering in walls or the ceiling can be an auditory clue.

Health Risks from Mice and Rodents

  • Hantavirus: Found in rodent saliva, droppings, and urine, hantavirus can be spread through the air when these materials are disturbed.
  • Rat-Bite Fever: Spread through bites or scratches from rats, or by consuming food or water contaminated by rats' urine.
  • Salmonellosis: Transmitted by consuming food or water contaminated by infected rodents.
laboratory mouse Lab rats

We covered it all in our latest post: Beyond the Nibbles: Common Diseases Spread by Rodents | Bio-One of Pittsburgh

Ensuring Health and Safety During Cleanup

When dealing with rodents, it is crucial to prioritize safety. Always wear protective gear, including:

  • Rubber or Latex Gloves: Protect hands from direct contact with rodents or their waste.
  • Respiratory Protection: Wear a mask when dealing with dust or the potential for airborne contaminants.
  • Eyewear: Reduce the risk of contact with eyes.
  • Cleaning Solutions: Use a bleach solution or a commercial disinfectant specifically for rodent cleanup.
  • Stiff Bristle Brush: For scrubbing hard surfaces.
  • Plastic Bags and Sealable Containers: For proper disposal of contaminated materials.
  • Rubber Gloves and Masks: Protect against direct contact with waste and harmful aerosols.

Getting Started with Cleaning Up After Mice

Disclaimer: In some cases, it may be best to hire professional cleaning services, especially when dealing with large infestations or environments where the safety of the cleanup team cannot be adequately assured.


Before starting, open windows or use fans to create airflow. Vent the area for at least 30 minutes to minimize the spread of airborne particles.

Removal of Droppings and Nests

Wear protective gear and use wet techniques, such as spraying or wiping with a damp cloth, to minimize dust and airborne particles.

Though highly suggested by some cleaning companies, the Centers for Disease Control and Prevention DO NOT recommend vacuuming rodent droppings and waste,  as this may lead to an increase in harmful airborne particles.


Once all droppings and nests have been removed, disinfect the area using a bleach solution or commercial EPA-approved disinfectant. Be sure to follow the instructions on the product label and allow for proper ventilation during and after application.

Storage and Disposal of Contaminated Materials

Once all contaminated materials have been removed and disinfected, place them in sealable plastic bags or containers for proper disposal. These should be labeled as hazardous waste and disposed of according to local regulations.

pest control and cleanup remediation technician

Preventing Future Infestations

After cleaning up after mice, it's important to take preventative measures to avoid future infestations. This includes sealing any cracks or holes in the walls or foundation of your home, storing food in airtight containers, and regularly cleaning up crumbs and spills.

Learn more about expert tips for cleaning up after mice by visiting: Cleaning Up After Rodents: The Most Important Areas to Tackle | Bio-One of South OC

How Bio-One of Pittsburgh Can Help

By following these comprehensive approaches, you can ensure your home is thoroughly clean and safe after experiencing a rodent infestation. Remember, above all, take every precaution to safeguard your health when undertaking any cleanup process.  It's always best to consult a professional cleaning company like Bio-One of Pittsburgh for expert assistance in dealing with rodent infestations.

Bio-One technicians inspecting damage on bathroom floor. Photo credit: Bio-One of Pittsburgh.

Compassion. Experience. Respect.

Bio-One of Pittsburgh is always ready to assist you in unexpected situations. Our expert specialists are always ready to assist you in dealing with highly pressurized situations that may be emotionally and physically draining, allowing you to focus on other vital activities while healing in a sanitary environment. Locally owned and operated, we provide the following:

Disinfection, sanitation, and decontamination services

  • Crime scene cleaning
  • Blood spill cleanup
  • Homicide and suicide cleanup
  • Unattended death cleanup
  • Biohazard cleanup
  • Feces and bodily fluids cleanup
  • Odor removal
  • Virus Disinfection
  • Fentanyl cleanup
  • Tear gas cleanup
  • Emergency vehicle decontamination
  • Sewage backup cleanup
  • Medical Waste disposal

Remediation & Hoarding cleanup services

  • Hoarding cleanup
  • Animal hoarding cleanup
  • Junk removal
  • Deep cleanup
  • Gross filth cleanup
  • Hazardous waste removal
  • Homeless encampment cleanup


Bio-One works closely with victim support centers nationwide and local authorities, communities, emergency services personnel, hoarding task forces, apartment communities, insurance companies, and other organizations to accomplish each customer's most efficient and superior service possible. 

Many crime scene cleanup companies may face unexpected, unfortunate life events. Still, Bio-One is the right choice because of our expertise and profoundly caring and discreet specialists.

We are proud members of the NAPO Pittsburgh - National Association of Productivity & Organizing Professionals

Serving the Greater Pittsburgh / Western Pennsylvania Area! 

Bio-One of Pittsburgh serves the following Pennsylvania counties: Allegheny County, Washington County, Beaver County, Butler County, Armstrong County, Westmoreland County, Lawrence County, Greene County, Fayette County, and Mercer County.

We also serve the following cities and surrounding communities: from Allison Park all the way to Creighton, Crescent, Cuddy Curtisville, Millvale, Monroeville, Oakmont, Pitcairn, Pleasant Hills, Plum, Port Vue, Presto, Rankin, Rennerdale, Rural Ridge, Russellton, Sharpsburg, South Park to Springdale, we are ready to help you.